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. Author manuscript; available in PMC: 2020 Dec 17.
Published in final edited form as: J Cell Biochem. 2018 Sep 7;120(1):519–532. doi: 10.1002/jcb.27407

Fig. 6. Effects of HNF4α mutations on the transcriptional activities of HNF4α in HEK293 cells.

Fig. 6.

(A) A schematic view of HNF4α2 protein structure. AF-1 & AF-2: Activation Function domain 1 & 2; DBD: DNA Binding Domain; H: Hinge; LBD: Ligand Binding Domain; F: F domain. The mutants in parentheses indicated the prior known names of HNF4α mutations; (B) The reporter activities of HNF4A-AS1-Pro-Luc, HNF1A-Pro-Luc and miR-194-Pro-Luc induced by wild-type and mutant HNF4α2. N=4, mean ± SE. * p<0.05 vs control. † p<0.05 vs wildtype HNF4α (HNF4α_WT).