Table 3.

Receiver operating characteristic curve derived sensitivity, specificity, likelihood ratio for a positive test, and likelihood ratio for a negative test of serum prostate-specific antigen at different cut-off levels

Criterion	Sensitivity (95% CI)	Specificity (95% CI)	LRP	LRN
≦1.0	21.2 (14.2-29.7)	96.0 (91.8-98.4)	5.24	0.82
≦2.0	38.1 (29.4-47.5)	93.6 (88.9-96.8)	6.00	0.66
≦3.0	39.8 (30.9-49.3)	93.1 (88.2-96.4)	5.74	0.65
≦4.0	42.4 (33.3-51.8)	91.9 (86.8-95.5)	5.24	0.63
≦5.0	43.2 (34.1-52.7)	90.8 (85.4-94.6)	4.67	0.63
≦6.0	47.5 (38.2-56.9)	90.8 (85.4-94.6)	5.13	0.58
≦7.0	50.0 (40.7-59.3)	90.8 (85.4-94.6)	5.41	0.55
≦8.0	54.2 (44.8-63.4)	90.8 (85.4-94.6)	5.86	0.50
≦9.0	61.0 (51.6-69.9)	90.2 (84.7-94.2)	6.21	0.43
≦10	64.4 (55.1-73.0)	90.2 (84.7-94.2)	6.55	0.39
≦11	65.3 (55.9-73.8)	89.6 (84.1-93.7)	6.27	0.39
≦12	66.9 (57.7-75.3)	89.6 (84.1-93.7)	6.43	0.37
≦13	67.8 (58.6-76.1)	88.4 (82.7-92.8)	5.86	0.36
≦14	70.3 (61.2-78.4)	88.4 (82.7-92.8)	6.08	0.34
≦15	73.7 (64.8-81.4)	87.3 (81.4-91.9)	5.80	0.30
≦16	74.6 (65.7-82.1)	85.5 (79.4-90.4)	5.16	0.30
≦17	76.3 (67.6-83.6)	84.4 (78.1-89.5)	4.89	0.28
≦18	78.0 (69.4-85.1)	84.4 (78.1-89.5)	5.00	0.26
≦19	78.8 (70.3-85.8)	83.8 (77.5-89.0)	4.87	0.25
≦20	78.8 (70.3-85.8)	82.7 (76.2-88.0)	4.54	0.26
≦21	78.8 (70.3-85.8)	82.1 (75.5-87.5)	4.40	0.26
≦22	80.5 (72.2-87.2)	81.5 (74.9-87.0)	4.35	0.24
≦23	81.4 (73.1-87.9)	80.9 (74.3-86.5)	4.27	0.23
≦24	82.2 (74.1-88.6)	80.9 (74.3-86.5)	4.31	0.22
≦25	83.1 (75.0-89.3)	79.8 (73.0-85.5)	4.11	0.21
≦26	83.9 (76.0-90.0)	78.6 (71.7-84.5)	3.92	0.20
≦27	84.7 (77.0-90.7)	77.5 (70.5-83.5)	3.76	0.20
≦28	86.4 (78.9-92.0)	75.7 (68.6-81.9)	3.56	0.18
≦29.16*	89.0 (81.9-94.0)	74.6 (67.4-80.9)	3.50	0.15
≦30	89.0 (81.9-94.0)	74.0 (66.8-80.4)	3.42	0.15
≦31	89.0 (81.9-94.0)	73.4 (66.2-79.8)	3.35	0.15

*Optimal cut off value; -: the value giving highest sensitivity; +: specificity LRP: Likelihood ratio for a positive test; LRN: Likelihood ratio for a negative test; CI: Confidence interval