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Alignment of the backbone atoms in mutated K1/K10 segment 1A (red cartoons) after cluster analyses of the equilibration trajectory for (a) hydrophobic and (b) polar mutations with the wild-type segment (blue cartoons). For greater clarity in the structural changes for the p.ARG156LEU and p.ARG156GLY mutations, green arrows denote regions that are highly perturbed after the hydrophobic mutations and equilibration.
