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. 2020 Dec 17;15(12):e0243857. doi: 10.1371/journal.pone.0243857

Fig 4. MiRNA WGCNA and mRNA:miRNA interaction.

Fig 4

A) NAc miRNA cluster dendrogram and module assignment with module-trait relationship heatmap, both as previously described in Fig 1. B) Bonferroni adjusted significant (p≤0.05) NAc mRNA/miRNA module ME correlations (Pearson’s). Alcohol and control groups are separated by color to emphasize sample clustering. C) Significant (FDR≤0.05) correlation (Pearson’s) between mir-449a and selected mRNA transcripts from the low network preserved NAcpurple module. D) PFC miRNA cluster dendrogram module assignment along with module-trait relationship heatmap. E) Bonferroni adjusted significant (p≤0.05) NAc mRNA:miRNA module ME correlations (Pearson’s).