Table 8.
Individuals with growth deficiency or facial features were over 2-fold more likely to have severe CNS dysfunction†
| Frequency | Unadjusted | Adjusted for Face or Growth | ||||
|---|---|---|---|---|---|---|
| N | CNS Rank 3* n (%) | OR | 95% CI | OR | 95% CI | |
| Growth Rank | ||||||
| 1 | 517 | 162 (31%) | Referent 1.0 | |||
| 2 | 96 | 36 (38%) | 1.32 | 0.84–2.07 | 1.25 | 0.79–1.98 |
| 3 | 79 | 39 (49%) | 2.14 | 1.32–3.45 | 1.77 | 1.07–2.91 |
| 4 | 43 | 24 (56%) | 2.77 | 1.47–5.20 | 1.96** | 1.01–3.81 |
| Face Rank | ||||||
| 1 | 182 | 52 (29%) | Referent 1.0 | |||
| 2 | 439 | 144 (33%) | 1.22 | 0.84–1.78 | 1.12 | 0.76–1.64 |
| 3 | 55 | 26 (47%) | 2.24 | 1.21–4.16 | 1.93 | 1.03–3.63 |
| 4 | 59 | 39 (66%) | 4.88 | 2.60–9.13 | 3.82 | 1.98–7.33 |
†
Odds Ratio (OR) and 95% confidence intervals for the association between the 4-Digit Code Face and Growth Ranks and severe CNS dysfunction (CNS Rank 3) among 735 patients 9 years of age or older (old enough to accurately assess CNS function).
*
CNS Rank 3 is defined by 3 or more domains of brain function, 2 or more SDs below the mean.
**
Explanation: The odds of CNS rank 3 for a patient with Rank 4 growth are 1.96 times the odds of CNS Rank 3 for a patient with Rank 1 growth, all other things being equal. 95% confidence intervals that do not include 1.00 are statistically significant at p < 0.05.