Table 9.

Infants/toddlers with sentinel physical features were most at risk for severe CNS dysfunction later in childhood^†

Sentinel physical feature	CNS Rank increased to Rank 3 at the second diagnostic evaluation
	No n (%)	Yes n (%)
Growth Rank at first evaluation*
1 (normal)	18 (54)	15 (46)
2 (mild)	3 (43)	4 (57)
3 (moderate)	1 (33)	2 (67)
4 (severe)	0 (0)	3 (100)
Face Rank at first evaluation**
1 (normal)	10 (83)	2 (17)
2 (mild)	7 (39)	11 (61)
3 (moderate)	2 (33)	4 (67)
4 (severe)	3 (30)	7 (70)
Microcephaly at first evaluation ***
Normal OFC	21 (51)	20 (49)
Microcephaly	1 (20)	4 (80)

^†Among 46 subjects with two evaluations when they were on average 4 and 10 years of age, respectively, those with growth deficiency, FAS facial features, or microcephaly at the first diagnostic evaluation were more likely to present with severe CNS dysfunction (CNS Rank 3) at their second diagnostic evaluation.

^*Chi² linear-by-linear association 3.7; P < 0.05.

^**Fisher exact for Rank 1 vs Ranks 2,3,4 P < 0.05.

^***Fisher’s Exact Test P = 0.20

OFC, occipital–frontal circumference