Fig 4. Effects of 18-hour WD on urinary electrolytes and urea in Cx37^-/- and WT mice.

Urinary concentrations of (A) Na⁺ and (B) K⁺ were not significantly different between genotypes after WD. In contrast, concentrations of (C) urea and (D) creatinine were ~15% and ~29% lower in Cx37^-/- compared to WT mice, respectively. Urinary Na⁺/creatinine and urea/creatinine were not different between genotypes (E and G, respectively); however, urinary K⁺/creatinine was significantly higher in in Cx37^-/- compared to WT mice (F). Data are expressed as mean ± SEM; n = 11–16. Data were analyzed by Student’s t-test, *P<0.05 versus WT.