Fig 4. Conservation analysis of the phosphatase and kinase domains.

A) Color code according to the degree of sequence conservation for each domain. Conservation scores are calculated based on the previous MSA. B) Number of amino acids classified according to their conservation scores for each domain. C) Prediction of the 3D structure of human PNKP colored according to the degree of conservation for each domain. The linker between the FHA and phosphatase domain shows low conservation scores, while the degree of greater conservation is in the phosphatase domain.