TABLE 3.
Multivariable Analyses of Sodium Correction Rate and Association With In-Hospital Mortality
| Multivariable Logistic Regression | Medical Information Mart for Intensive Care III (n = 2,982) | Electronic ICU (n = 8,594) | ||
|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | |
| Age (numeric, per 10 yr) | 1.04 (1.03–1.05) | < 0.001 | 1.00 (1.00–1.01) | 0.296 |
| Male (binary) | 1.02 (0.98–1.07) | 0.308 | 1.02 (0.99–1.04) | 0.196 |
| Sodium correction rate (numeric, per 1 mmol/L/hr) | 1.08 (1.03–1.13) | 0.003 | 1.10 (1.06–1.13) | < 0.001 |
| APS III (numeric, per 10 points) | 1.04 (1.03–1.05) | < 0.001 | — | — |
| APACHE IV (numeric, per 10 points) | — | — | 1.03 (1.03–1.03) | < 0.001 |
| Number of samples (numeric, per 10 samples) | 0.98 (0.97–0.99) | < 0.001 | 0.97 (0.97–0.98) | < 0.001 |
| Multivariable Cox Regression | HR (95% CI) | p | HR (95% CI) | p |
| Age (numeric, per 10 yr) | 1.12 (1.07–1.18) | < 0.001 | 1.00 (0.96–1.02) | 0.975 |
| Male (binary) | 1.07 (0.94–1.22) | 0.313 | 1.08 (0.96–1.21) | 0.225 |
| Sodium correction rate (numeric, per 1 mmol/L/hr) | 1.32 (1.16–1.51) | < 0.001 | 1.48 (1.33–1.64) | < 0.001 |
| APS III (numeric, per 10 points) | 1.13 (1.09–1.16) | < 0.001 | — | — |
| APACHE IV (numeric, per 10 points) | — | — | 1.18 (1.16–1.20) | < 0.001 |
| Number of samples (numeric, per 10 samples) | 0.85 (0.81–0.89) | < 0.001 | 0.80 (0.76–0.85) | < 0.001 |
APACHE IV = Acute Physiology and Chronic Health Evaluation IV, APS III = Acute Physiology Score III, HR = hazard ratio, OR = odds ratio.
Dash indicates when data is not available in the specific database. Hypernatremia-related variables is marked as bold.