Figure 4.

Two mechanisms for suppressing totipotency outside the germline in an ancestral lineage with both sequestered germline stem cells and dispersed non-germline stem cells enabling WBR. Forcing lineage commitment (left branch) suppresses totipotency outside the germline and hence WBR while leaving enabled at least partial somatic cell replacement by lineage-committed stem cells. Co-opting all totipotent cells to the germline (right branch) or killing non-germline stem cells suppresses not only WBR but also somatic cell replacement