Fig 4. MOV10 restricts SFTSV infection and pathogenicity in vivo.

C57/BL6 mice (n = 5/group) were transduced with the viral vectors encoding control or Mov10-targeting shRNAs (5×10⁷ TU) via caudal vein, followed by infection with SFTSV (10⁵ TCID50) via subcutaneous injection, 7 d posttransduction. Three days postinfection, mice were sacrificed for evaluation of Mov10 expression by qPCR (A) and IB (B) analyses and for quantification of viral S RNA copy (C and D), platelet count (E), and ALT level (F) in the indicated tissues as described in Materials and Methods. Data are means ± SD. *p < 0.05; **p < 0.01. Dotted lines represent the average platelet count (E) or ALT level (F) of control mice without transduction or infection (n = 5) for reference. See also S6 Fig.