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. Author manuscript; available in PMC: 2020 Dec 17.
Published in final edited form as: Neuroscience. 2019 May 7;410:274–292. doi: 10.1016/j.neuroscience.2019.04.047

Fig. 10. Plasticity, stress and kinase gene and protein densities are altered differentially within hippocampal circuits in females and males both in saline rats and following oxycodone CPP.

Fig. 10.

A. In CA3, saline rats have: 1) greater ARC protein density and Arc expression in Sal-females compared to Sal-males; 2) greater Crhr2 expression in Sal-males compared to Sal-females. In DG, Sal-female rats have greater pAKT density compared to Sal-males. B. After CPP, Oxy-females have: 1) increases in plasticity protein markers for ARC in CA3 pyramidal cells (pc) and NPY in hilar interneurons (in) but decreases in Npy mRNA expression in the medial hippocampus; 2) increases in the mRNA expression for the stress marker Crhr2 in the CA2/3 region; and 3) increases in Akt1 mRNA expression and pAKT-ir density in CA3 pyramidal cells and decreases in pMAPK-ir density in CA1 pyramidal cells. C. After CPP, Oxy-males have: 1) increases in the mRNA expression of Bdnf which is known to be produced in granule cells (Scharfman and MacLusky, 2014); 2) elevations in pMAPK-ir densities in the dentate hilus which harbors newly generated granule cells; and 3) increases in Arc mRNA expression and CRHR1-SIG particles in the soma of CA3 pyramidal cells.