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. Author manuscript; available in PMC: 2020 Dec 17.
Published in final edited form as: Neuroscience. 2019 May 7;410:274–292. doi: 10.1016/j.neuroscience.2019.04.047

Fig. 3. Sex differences in Arc mRNA expression and ARC protein densities following oxycodone CPP.

Fig. 3.

A. In the lateral hippocampus (LH), Sal-females (SF) had significantly more Arc mRNA expression than Sal-males (SM). Moreover, Sal-males had significantly less Arc mRNA expression than Oxy-males (OM). B. In the medial hippocampus (MH), Sal-males had a trend towards less Arc mRNA expression than Oxy-males. OF, Oxy-females. C. Representative light microscopic micrographs show higher densities of ARC-ir in the CA2/3a pyramidal cell layer (PCL) in an Oxy-female compared to an Oxy-male. D. In CA2/3a, the density of ARC-ir was significantly greater in stratum oriens (SO) and the PCL of Oxy-females compared to Oxy-males. SR, stratum radiatum. E. Representative light microscopic micrographs show lower densities of ARC-ir in the CA3b pyramidal cell layer (PCL) from a Sal-female compared to an Oxy-female. F. In CA3b, the density of ARC-ir was significantly greater in stratum lucidum (SLu) and SR of Sal-females compared to Sal-males. The density of ARC-ir was significantly greater in Oxy-females compared to Sal-females in the PCL. * p < 0.05, ^ p = 0.087, ap = 0.042, bp = 0.022, cp = 0.018, dp = 0.010.