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. Author manuscript; available in PMC: 2020 Dec 17.
Published in final edited form as: Neuroscience. 2019 May 7;410:274–292. doi: 10.1016/j.neuroscience.2019.04.047

Fig 6. Sex differences in Crhr1 and Crhr2 mRNA expression and CRHR1 protein densities following oxycodone CPP.

Fig 6.

A. In the lateral hippocampus (LH), Sal-females (SF) had a trend towards less Crhr1 mRNA expression than Oxy-females (OF). Oxy-females had significantly more Crhr1 mRNA expression than Oxy-males (OM). B. In the lateral hippocampus, Sal-females had significantly less Crhr2 mRNA expression than Sal-males (SM) and Oxy-females. C & D. Representative electron micrographs show that fewer CRHR1-SIG particles (arrows) are found in the cytoplasm of soma from a Sal-male compared to an Oxy-male. In both micrographs, a CRHR1-SIG particle is found on the nuclear membrane (arrowhead). N, nucleus. Bar = 500 nm. E. In CA3, significantly more CRHR1-SIG particles are found in the Oxy-males compared to the Sal-males and Oxy-females. F. The density of CRHR1-SIG particles in CA3 dendrites is not different between the 4 groups. * p < 0.05, Λ p = 0.081.