| Gene names |
Gene type |
Potential roles in tumorigenesis and tumor progression |
Relationship between overexpression/ overabundance with cancer prognosis |
| PDK1 |
mRNA |
1. Upregulated PDK1 was associated with Warburg metabolic and malignant phenotype of cancer [38]; |
1.shorter survival: non-small cell lung cancer [39], nasopharyngeal carcinoma[40], and head and neck squamous cancer [41] |
|
|
2. Knockdown of PDK1 decreased invasiveness and inhibited tumor growth [38] |
2. prolonged survival: Colon Cancer [42] |
| EEF1A1 |
mRNA |
Overexpression of eEF1A1: related to cancer cell proliferation, invasion, and migration [45] |
|
| NR3C1 |
mRNA |
Downregulation due to methylation: breast cancer [47], colorectal tumors [48] |
1. shorter survival: Estrogen-negative (ER-) breast cancer [49], ovarian cancer [50] |
|
|
|
2. prolonged survival: ER+ breast cancer [49] |
| THOC1 |
mRNA |
1. Upregulated in colorectal cancer [53], breast cancer [54], and cancer cell [54] |
1. shorter survival: colorectal cancer [53] |
|
|
2. High Thoc1 expression associated with prostate cancer aggressiveness and recurrence [55] |
|
| APBA2 |
mRNA |
1. Hypermethylated in gastric cancer [56], colorectal carcinoma and gastric carcinoma [57, 58] |
|
|
|
2. Upregulated in early Endometrial endometrioid carcinoma [57] |
|
| SLC43A2 |
mRNA |
Associated with gastric cancer [59] |
|
| SNHG16 |
lncRNA |
1. Overexpression in non-small cell lung cancer [60] and oral squamous cell carcinoma [61]. |
1. shorter survival: non-small cell lung cancer [60] |
|
|
2. Associated with cancer cell proliferation, migration and invasion [60, 61] |
|
