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. 2020 Nov 10;12(22):22719–22743. doi: 10.18632/aging.103891

Figure 8.

Figure 8

Excessive secretion of gWAT-derived exosomal miR-222 promotes obesity-induced insulin resistance. Upregulation of circulating gWAT-derived exosomal miR-222 promote insulin resistance by repressing IRS-1 expression in the liver and skeletal muscle tissues of the HFD-fed obese model mice.