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The mutation frequency of the ten hub metabolic genes in the ccRCC patients (TCGA, Firehose Legacy). (A) The overall mutation frequency of the hub metabolic genes in 446 ccRCC patients. (B) The mutation frequency of the individual hub metabolic genes in 446 ccRCC patients. (C) Kaplan–Meier survival curves show the OS of ccRCC patients with mutations in the hub metabolic genes (n=172) compared to those without mutations in the hub metabolic genes (n=274).
