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. 2020 Nov 18;12(22):23165–23186. doi: 10.18632/aging.104088

Table 1. KEGG pathway and GO enrichment analysis of differentially expressed metabolic genes.

GO term P-value FDR
Biological processes small molecule catabolic process 0 0
organic acid biosynthetic process 6.55E-14 2.78E-11
organic hydroxy compound metabolic process 3.20E-10 9.06E-8
cellular amino acid metabolic process 4.93E-10 1.05E-7
generation of precursor metabolites and energy 6.84E-10 1.16E-7
fatty acid derivative metabolic process 3.62E-9 5.12E-7
monosaccharide metabolic process 5.46E-9 6.63E-7
nucleoside phosphate biosynthetic process 1.17E-8 0.000001
ribonucleotide metabolic process 1.26E-8 0.000001
fatty acid metabolic process 2.06E-8 0.000002
Cellular component mitochondrial matrix 0.000070 0.012090
ficolin-1-rich granule 0.000265 0.022800
myelin sheath 0.000774 0.044374
Molecular function cofactor binding 6.66E-16 1.88E-13
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 7.64E-14 1.08E-11
lyase activity 1.11E-11 1.04E-9
organic acid binding 9.99E-9 6.93E-7
iron ion binding 1.23E-8 6.93E-7
monooxygenase activity 1.75E-8 8.24E-7
transferase activity, transferring glycosyl groups 4.15E-8 0.000002
vitamin binding 5.28E-8 0.000002
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.000003 0.000084
oxidoreductase activity, acting on CH-OH group of donors 0.000003 0.000095
KEGG pathway metabolic pathways 0 0
drug metabolism 2.43E-12 3.71E-10
retinol metabolism 3.41E-12 3.71E-10
chemical carcinogenesis 6.20E-11 3.62E-9
purine metabolism 6.67E-11 3.62E-9
porphyrin and chlorophyll metabolism 1.24E-9 5.76E-8
steroid hormone biosynthesis 3.52E-9 1.43E-7
metabolism of xenobiotics by cytochrome P450 3.97E-9 1.44E-7
carbon metabolism 6.20E-8 0.000002