Figure 4.

Drug-selected melanoma cells had lower levels of kinase activation than parental cells. (A) phosphor-kinase antibody array showed differential levels of different phosphor-proteins in parental or drug-selected cells. The quantification of blot intensities were shown (n=2; data were mean ±SD; *, p < 0.05.). (B) Western blot analysis of phosphor-tyrosine proteins in parental or drug-selected cells. Significantly lower levels of phosphor-proteins in drug-selected cells were indicated by arrows. Line-histograms were generated by Image J.