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. 2020 Oct 13;49(5):1441–1442e. doi: 10.1093/ije/dyaa135

Table 2.

New investigations conducted at SABRE study follow-up visit 3 (2014–18) and their key measurementsa

Investigation Key measurements Sub-sample
Physical function
6MST

  • Exercise capacity

  • Heart rate

  • Sub-maximal and estimated maximum whole-body oxygen consumption (VO2)

  • BP response
 Grip strength

  • Muscle strength

  • BP response to grip (30% of max)
 Datagait test

  • Stride length

  • Self-selected walking pace

  • Walking efficiency and control
  Risk of fall ‘Quick Screen’

  • Visual acuity

  • Tactile sensitivity

  • Near tandem stand test

  • Alternate step test

  • Sit-to-stand test
Cardiovascular/respiratory
 Orthostatic challenge Change in BP from lying to standing
 Vicorder Pulse wave velocity
 5-min resting ECG Heart rate variability
 ASL (added to cerebral MRI protocol) Cerebral blood flow
 Spirometry

  • Forced vital capacity (FVC)

  • Forced expired volume in first second (FEV1)
Body composition
 DEXA

  • Body composition (fat/lean mass)

  • Bone mineral content and density (hip and lumbar spine)

  • Aortic calcification
Metabolic
 Liver ultrasound

  • Elastography

  • Hepato–renal ratio

  •  Non-fasting blood sample (after early light breakfast)

  •  Saliva sample

  • Stored samples (whole blood, plasma, serum, PAXgene RNA, PAXgene DNA)

  • Cortisol, amylase
 Scout AGE reader (forearm) Advanced glycation end products (AGEs) √
 Muscle NIRS

  • Muscle haemodynamic response to exercise

  • Local muscle oxygen consumption

  • Muscle oxidative capacity

  • √

  • √
Questionnaire
 Self-report Perceptions of physical disability and ageing. Hearing, vision, dental health. Caring responsibilities and need for care, receipt of benefit payments, healthcare resource use. Reproductive health and menopause. Childhood diet and physical activity
a

AGEs, advanced glycation end-products; ASL, arterial spin labelling; BP, blood pressure; NIRS, near-infrared spectroscopy.