Table 2.
Main MR, split-sample MR and multivariable-adjusted analysis results for all outcomes where the main or split-sample Mendelian randomization analysis had a P-value less than 0.0026
| Health condition/risk factor | Outcome | N | Main MR analysis |
Split-sample MR analysis |
Multivariable adjusted analysis |
P for endogeneity | |||
|---|---|---|---|---|---|---|---|---|---|
| Beta (95% CI) | P | Beta (95% CI) | P | Beta (95% CI) | P | ||||
| Alcohol intake (5 units/week) | Cohabiting | 251 512 | −0.8% (-1.9% to 0.3%) | 1.41E-01 | −1.5% (-2.4% to -0.6%) | 1.56E-03 | −0.4% (-0.4% to -0.3%) | 0.00E+00 | 4.30E-01 |
| Alcohol intake (5 units/week) | Household income | 219 924 | £-2446 (£-3362 to £-1530) | 1.65E-07 | £-509 (£-1264 to £247) | 1.87E-01 | £442 (£400 to £484) | 0.00E+00 | 1.54E-10 |
| Alcohol intake (5 units/week) | Own accommodation lived in | 249 886 | −1.8% (-2.4% to -1.2%) | 2.34E-08 | −1.2% (-1.7% to -0.6%) | 2.65E-05 | −0.2% (-0.2% to -0.1%) | 4.30E-25 | 2.24E-07 |
| Alcohol intake (5 units/week) | TDI at recruitment | 252 287 | 0.18 (0.11 to 0.25) | 2.56E-07 | 0.14 (0.08 to 0.19) | 3.66E-06 | 0.03 (0.03 to 0.04) | 0.00E+00 | 1.78E-05 |
| Alcohol intake (5 units/week) | Weekly friend visits | 251 264 | −2.1% (-3.2% to -1.1%) | 7.91E-05 | −1.1% (-2.0% to -0.2%) | 1.24E-02 | −0.0% (-0.1% to 0.0%) | 8.79E-02 | 9.03E-05 |
| Alcohol intake (5 units/week) | Weekly leisure or social activity | 252 094 | 1.8% (0.7% to 3.0%) | 2.10E-03 | 0.2% (-0.8% to 1.1%) | 7.41E-01 | 0.8% (0.8% to 0.9%) | 0.00E+00 | 9.61E-02 |
| Asthma | Cohabiting | 335 271 | −11.0% (-17.9% to -4.0%) | 2.08E-03 | −3.0% (-7.7% to 1.6%) | 1.96E-01 | −1.6% (-2.0% to -1.1%) | 1.76E-12 | 8.15E-03 |
| Asthma | Household income | 290 457 | £-13 474 (£-18 749 to £-8199) | 5.54E-07 | £-6462 (£-9927 to £-2996) | 2.58E-04 | £-693 (£-1029 to £-357) | 5.35E-05 | 1.57E-06 |
| Asthma | University education | 276 784 | −17.1% (-25.4% to -8.7%) | 5.83E-05 | −9.3% (-14.7% to -3.9%) | 7.37E-04 | 2.1% (1.6% to 2.7%) | 1.20E-14 | 4.87E-06 |
| Body mass index (5 kg/m2) | Household income | 289 594 | £-2777 (£-3692 to £-1863) | 2.65E-09 | £-4169 (£-4982 to £-3356) | 9.15E-24 | £-2332 (£-2451 to £-2212) | 0.00E+00 | 3.36E-01 |
| Body mass index (5 kg/m2) | Lonely | 331 018 | 2.4% (1.4% to 3.5%) | 7.06E-06 | 3.3% (2.3% to 4.2%) | 1.23E-11 | 2.7% (2.6% to 2.9%) | 0.00E+00 | 5.53E-01 |
| Body mass index (5 kg/m2) | Non-employed vs employed (retired excluded) | 215 625 | 1.4% (0.4% to 2.5%) | 5.66E-03 | 2.3% (1.3% to 3.2%) | 1.58E-06 | 1.9% (1.8% to 2.0%) | 0.00E+00 | 3.75E-01 |
| Body mass index (5 kg/m2) | Non-employed vs employed/retired | 333 446 | 0.9% (0.2% to 1.6%) | 1.34E-02 | 1.5% (0.8% to 2.1%) | 8.27E-06 | 1.3% (1.2% to 1.4%) | 0.00E+00 | 2.55E-01 |
| Body mass index (5 kg/m2) | Own accommodation lived in | 331 854 | −1.6% (-2.4% to -0.8%) | 5.75E-05 | −3.1% (-3.8% to -2.4%) | 2.03E-18 | −2.6% (-2.7% to -2.5%) | 0.00E+00 | 9.44E-03 |
| Body mass index (5 kg/m2) | Satisfied with financial situation | 110 373 | −1.6% (-3.2% to 0.0%) | 5.41E-02 | −3.1% (-4.5% to -1.6%) | 3.72E-05 | −3.4% (-3.6% to -3.2%) | 0.00E+00 | 2.63E-02 |
| Body mass index (5 kg/m2) | Satisfied with health | 110 513 | −5.2% (-6.8% to -3.5%) | 9.18E-10 | −6.7% (-8.1% to -5.2%) | 1.05E-18 | −7.6% (-7.8% to -7.4%) | 0.00E+00 | 3.53E-03 |
| Body mass index (5 kg/m2) | Skilled job | 218 811 | −2.3% (-3.5% to -1.0%) | 4.52E-04 | −4.5% (-5.7% to -3.4%) | 5.23E-15 | −2.3% (-2.5% to -2.1%) | 0.00E+00 | 9.41E-01 |
| Body mass index (5 kg/m2) | TDI at recruitment | 335 524 | 0.25 (0.17 to 0.33) | 8.25E-11 | 0.35 (0.29 to 0.42) | 7.44E-25 | 0.29 (0.28 to 0.30) | 0.00E+00 | 2.94E-01 |
| Body mass index (5 kg/m2) | University education | 276 021 | −2.9% (-4.4% to -1.5%) | 9.41E-05 | −7.2% (-8.6% to -5.9%) | 5.03E-27 | −5.4% (-5.5% to -5.2%) | 0.00E+00 | 1.12E-03 |
| Body mass index (5 kg/m2) | Weekly leisure or social activity | 335 096 | −1.4% (-2.7% to -0.1%) | 2.89E-02 | −3.0% (-4.2% to -1.9%) | 1.87E-07 | −2.6% (-2.8% to -2.5%) | 0.00E+00 | 5.51E-02 |
| Depression | Happy | 69 646 | −19.1% (-28.4% to -9.8%) | 5.33E-05 | −7.4% (-7.7% to -7.0%) | 0.00E+00 | 9.81E-03 | ||
| Depression | Lonely | 92 977 | 58.7% (38.5% to 78.9%) | 1.19E-08 | 18.4% (17.8% to 19.0%) | 0.00E+00 | 1.93E-05 | ||
| Depression | Satisfied with family relationships | 69 271 | −19.3% (-30.4% to -8.1%) | 7.42E-04 | −6.9% (-7.2% to -6.5%) | 0.00E+00 | 2.56E-02 | ||
| Depression | Satisfied with financial situation | 69 554 | −26.4% (-41.9% to -10.9%) | 8.14E-04 | −9.1% (-9.7% to -8.6%) | 0.00E+00 | 2.45E-02 | ||
| Depression | Satisfied with health | 69 650 | −29.1% (-44.6% to -13.6%) | 2.28E-04 | −11.1% (-11.6% to -10.5%) | 0.00E+00 | 1.84E-02 | ||
| Eczema | Household income | 290 457 | £-46 965 (£-71 028 to £-22 902) | 1.31E-04 | £-12 545 (£-30 268 to £5177) | 1.65E-01 | £158 (£-544 to £859) | 6.60E-01 | 7.42E-05 |
| Lifetime smoking (SD) | Cohabiting | 334 122 | −5.4% (-8.8% to -2.0%) | 1.74E-03 | −4.5% (-4.7% to -4.4%) | 0.00E+00 | |||
| Lifetime smoking (SD) | Household income | 289 728 | £-7585 (£-10 155 to £-5014) | 7.31E-09 | £-4088 (£-4201 to £-3976) | 0.00E+00 | |||
| Lifetime smoking (SD) | Non-employed vs employed (retired excluded) | 215 665 | 5.9% (2.9% to 8.9%) | 1.41E-04 | 4.1% (4.0% to 4.2%) | 0.00E+00 | |||
| Lifetime smoking (SD) | Non-employed vs employed/retired | 333 384 | 4.2% (2.1% to 6.2%) | 9.42E-05 | 2.7% (2.6% to 2.8%) | 0.00E+00 | |||
| Lifetime smoking (SD) | Own accommodation lived in | 331 776 | −8.6% (-10.7% to -6.4%) | 8.83E-15 | −5.1% (-5.2% to -5.0%) | 0.00E+00 | |||
| Lifetime smoking (SD) | Satisfied with financial situation | 110 501 | −10.0% (-14.7% to -5.3%) | 2.75E-05 | −4.0% (-4.2% to -3.8%) | 0.00E+00 | |||
| Lifetime smoking (SD) | Satisfied with health | 110 649 | −8.4% (-13.3% to -3.6%) | 5.88E-04 | −3.7% (-3.9% to -3.5%) | 0.00E+00 | |||
| Lifetime smoking (SD) | Skilled job | 218 695 | −8.6% (-12.7% to -4.5%) | 4.31E-05 | −4.0% (-4.2% to -3.9%) | 0.00E+00 | |||
| Lifetime smoking (SD) | TDI at recruitment | 335 434 | 0.98 (0.76 to 1.19) | 4.42E-19 | 0.53 (0.52 to 0.54) | 0.00E+00 | |||
| Lifetime smoking (SD) | University education | 276 177 | −15.9% (-20.7% to -11.1%) | 7.32E-11 | −6.0% (-6.2% to -5.8%) | 0.00E+00 | |||
| Migraine | Weekly leisure or social activity | 336 170 | −47.9% (-71.1% to -24.7%) | 5.15E-05 | −26.3% (-57.7% to 5.2%) | 1.01E-01 | −2.9% (-3.8% to -2.0%) | 2.02E-10 | 1.12E-04 |
| Smoking initiation | Household income | 289 728 | £-22 838 (£-31 354 to £-14 321) | 1.47E-07 | £-18 545 (£-25 572 to £-11 519) | 2.30E-07 | £-5974 (£-6220 to £-5728) | 0.00E+00 | 6.24E-05 |
| Smoking initiation | Non-employed vs employed (retired excluded) | 215 665 | 19.0% (9.0% to 29.0%) | 2.07E-04 | 10.0% (1.7% to 18.3%) | 1.87E-02 | 5.3% (5.0% to 5.6%) | 0.00E+00 | 6.62E-03 |
| Smoking initiation | Non-employed vs employed/retired | 333 384 | 13.3% (6.3% to 20.2%) | 1.78E-04 | 6.4% (0.9% to 11.9%) | 2.28E-02 | 3.6% (3.4% to 3.7%) | 0.00E+00 | 5.35E-03 |
| Smoking initiation | Own accommodation lived in | 331 776 | −20.8% (-28.2% to -13.4%) | 3.90E-08 | −16.3% (-22.1% to -10.5%) | 3.13E-08 | −6.7% (-6.9% to -6.5%) | 0.00E+00 | 1.27E-04 |
| Smoking initiation | Satisfied with financial situation | 110 501 | −23.6% (-38.5% to -8.7%) | 1.86E-03 | −22.7% (-36.0% to -9.4%) | 8.22E-04 | −5.7% (-6.2% to -5.3%) | 0.00E+00 | 1.50E-02 |
| Smoking initiation | Satisfied with health | 110 649 | −35.4% (-51.2% to -19.5%) | 1.21E-05 | −22.4% (-36.0% to -8.9%) | 1.20E-03 | −5.6% (-6.0% to -5.2%) | 0.00E+00 | 7.13E-05 |
| Smoking initiation | Skilled job | 218 695 | −37.0% (-50.0% to -23.9%) | 2.96E-08 | −14.1% (-24.3% to -3.9%) | 6.61E-03 | −5.5% (-5.9% to -5.2%) | 0.00E+00 | 5.00E-07 |
| Smoking initiation | TDI at recruitment | 335 434 | 1.73 (1.02 to 2.44) | 1.69E-06 | 2.26 (1.68 to 2.84) | 2.41E-14 | 0.79 (0.77 to 0.81) | 0.00E+00 | 8.58E-03 |
| Smoking initiation | University education | 276 177 | −65.9% (-81.4% to -50.4%) | 9.01E-17 | −35.7% (-47.1% to -24.2%) | 9.56E-10 | −9.7% (-10.1% to -9.3%) | 0.00E+00 | 1.19E-15 |
| Smoking initiation | Weekly friend visits | 333 955 | 19.8% (9.2% to 30.5%) | 2.70E-04 | −2.8% (-11.2% to 5.6%) | 5.13E-01 | −0.4% (-0.7% to -0.1%) | 4.44E-03 | 1.32E-04 |
MR, Mendelian randomization; SD, standard deviation; vs, versus.