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. Author manuscript; available in PMC: 2021 Oct 14.
Published in final edited form as: J Ind Microbiol Biotechnol. 2020 Oct 14;47(9-10):877–887. doi: 10.1007/s10295-020-02317-0

Fig. 3. 4-Hydroxy-2-alkylquinolines and substituted congeners.

Fig. 3.

(A) The hmq gene cluster in B. thailandensis (Bt) and B. pseudomallei (Bp) and the homologous pqs gene cluster in P. aeruginosa (Pa). Shading of Pa proteins indicates % sequence identity to Bt sequences. Light grey, 50–60%; dark grey, 30–40%; black, no homology. Bt and Bp proteins are >85% identical. (B) Structures of HMNQ (4-hydroxy-3-methyl-2-nonenylquinoline) and HQNO (2-heptyl-4(1H)-quinoline N-oxide). (C) Biosynthesis of hydroxyl-alkylquinolines by hmq gene products in B. thailandensis/B. pseudomallei and by pqs gene products in P. aeruginosa. The specific steps are described in the text.