Table 1.
Characteristics at baseline and after trauma but prior to start of resuscitation
| Control | ADAMTS-13 | |||
|---|---|---|---|---|
| Baseline | Hemorrhagic shock | Baseline | Hemorrhagic shock | |
| Clinical parameters | ||||
| n | 7 | 8 | ||
| Weight (g) | 373.6 (13.4) | 360.6 (24.8) | ||
| Temperature (°C) | 36.6 (0.8) | 36.9 (0.5) | 36.8 (0.6) | 36.8 (0.9) |
| Chemical lab | ||||
| Hemoglobin level (g/dL) | 14.0 (1.2) | 11.1 (1.0)† | 15.7 (0.5)* | 11.7 (0.6)† |
| Creatinine (μmol/L) | 25.4 (3.5) | ND | 23.4 (2.9) | ND |
| ASAT (U/L) | 63.9 (4.0) | ND | 63.3 (9.5) | ND |
| ALAT (U/L) | 54.6 (4.1) | ND | 53.1 (6.9) | ND |
| LDH (U/L) | 153.7 (89.0) | ND | 129.6 (49.1) | ND |
| vWF antigen (% of poolplasma) | 72 (29–84) | ND | 94 (86–101)* | ND |
| Blood gas | ||||
| pH | 7.44 (0.07) | 7.32 (0.11) | 7.38 (0.04) | 7.33 (0.07) |
| pCO2 (mmHg) | 35.4 (5.3) | 28.2 (8.7)† | 41.0 (7.4) | 34.6 (6.6) |
| HCO3− (mEq/L) | 23.3 (1.9) | 15.1 (6.5)† | 23.6 (2.5) | 17.5 (1.8)† |
| BD (mmol/L) | − 0.5 (2.6) | − 9.9 (7.5)† | − 1.4 (1.6) | − 7.6 (2.1)† |
| Lactate (mmol/L) | 0.9 (0.3) | 5.2 (4.7) | 0.9 (0.3) | 3.7 (1.2)† |
| Hemodynamics | ||||
| MAP (mmHg) | 133 (15) | 43 (11)† | 149 (9) | 44 (3)† |
| Heartrate (bpm) | 282 (32) | 265 (54) | 270 (18) | 252 (31) |
| ROTEM | ||||
| Clotting time (s) | 49.6 (5.5) | 49.3 (3.1) | 49.6 (4.6) | 43.1 (5.0)† |
| Mean clot firmness (mm) | 69.7 (2.9) | 64.0 (4.7)† | 69.9 (1.5) | 68.9 (2.1) |
| α-angle (°) | 81.7 (1.1) | 80.1 (1.8)† | 82.5 (0.5) | 81.9 (0.6)† |
| Maximum lysis (%) | 5.9 (3.1) | 0.9 (0.7)† | 2.3 (2.3)* | 0.9 (1.5)† |
Values are presented as mean and standard deviation (SD) or median and interquartile range (IQR)
BD base deficit, MAP mean arterial pressure, ND not done, NA not applicable
*Significantly different from control, p < 0.05
†Significantly different from baseline, p < 0.05