Table 2.
Stratification analysis for the meta-analysis with overall survival (OS) in patients with cancer.
| Subgroup | No. of cohorts | No. of patients | Pooled HR (95% CI) | P | Heterogeneity | |
|---|---|---|---|---|---|---|
| I 2 (%) | P h | |||||
| Altogether | 20 | 5716 | 2.12 (1.80-2.94) | <0.001 | 48.1 | 0.009 |
| Publishing time | ||||||
| <2019 | 6 | 1794 | 1.86 (1.55-2.23) | <0.001 | 11.9 | 0.339 |
| ≥2019 | 14 | 3922 | 2.30 (1.80-2.94) | <0.001 | 57.3 | 0.004 |
| Country | ||||||
| China | 19 | 5616 | 2.14 (1.80-2.54) | <0.001 | 50.8 | 0.006 |
| Korea | 1 | 100 | 1.77 (0.74-4.24) | NA | NA | NA |
| Sample capacity | ||||||
| <230 | 10 | 1541 | 2.52 (1.80-3.53) | <0.001 | 62.2 | 0.005 |
| ≥230 | 11 | 4175 | 1.81 (1.58-2.07) | <0.001 | 5.7 | 0.388 |
| Cutoff value | ||||||
| <0.5 | 14 | 3040 | 2.22 (1.76-2.81) | <0.001 | 60.2 | 0.002 |
| ≥0.5 | 6 | 2676 | 1.97 (1.63-2.38) | <0.001 | 0 | 0.575 |
| Cancer system | ||||||
| Digestive cancer | 8 | 1594 | 2.13 (1.57-2.87) | <0.001 | 52.2 | 0.041 |
| Respiratory cancer | 7 | 1831 | 1.86 (1.51-2.28) | <0.001 | 25.6 | 0.234 |
| Urinary cancer | 3 | 1315 | 2.98 (1.41-6.32) | 0.004 | 81 | 0.005 |
| Breast cancer | 1 | 746 | 2.24 (1.03-4.88) | NA | NA | NA |
| Gynecological cancers | 1 | 230 | 3.02 (1.23-7.40) | NA | NA | NA |
| Primary therapy | ||||||
| With chemotherapy | 5 | 1155 | 1.88 (1.44-2.45) | <0.001 | 42.6 | 0.137 |
| With radiotherapy | 1 | 122 | 1.70 (1.03-2.80) | NA | NA | NA |
| With surgery | 11 | 3878 | 2.64 (1.97-3.54) | <0.001 | 57.3 | 0.009 |
| Mixed | 2 | 324 | 1.67 (1.16-2.40) | 0.006 | 0 | 0.889 |
| Without treatment | 1 | 237 | 1.69 (1.16-2.47) | NA | NA | NA |
| Analytic method | ||||||
| Univariate | 3 | 387 | 2.88 (1.28-6.48) | 0.011 | 77.2 | 0.013 |
| Multivariate | 17 | 5329 | 1.99 (1.70-2.32) | <0.001 | 35.4 | 0.074 |