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. 2020 Dec 10;2020:8880244. doi: 10.1155/2020/8880244

Figure 1.

Figure 1

LIF treatment increases spleen weight after MCAO in aged animals. Spleen weights were measured after euthanization and normalized to the average spleen weight for sham-operated male (n = 9) and female animals (n = 8). The average spleen size among LIF-treated males (n = 23) was significantly higher than that among PBS-treated males (n = 19; ∗∗p < 0.01), but not sham males. Although there was a significant decrease in spleen size after MCAO among female rats (∗∗∗p < 0.001), spleens from LIF-treated female rats were significantly larger than spleens from sham (∗∗∗p < 0.001) and MCAO+PBS females (∗∗∗∗p < 0.0001). Furthermore, female MCAO+PBS rats (n = 14) showed a significantly larger decrease in spleen weight compared to PBS-treated males (∗p < 0.05). However, LIF-treated females (n = 16) had significantly larger spleens compared to their male counterparts (∗∗∗p < 0.001). Male sham n = 8‐24 per treatment group.