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. 2020 Dec 10;2020:8880244. doi: 10.1155/2020/8880244

Figure 5.

Figure 5

Sex and treatment change levels of IFNγ and IFNγ-inducible inflammatory mediators. (a) There was no significant difference in IFNγ levels in the spleens of male or female rats after MCAO. n = 4 per treatment group for all groups except sham groups (n = 2). (b) Relative levels of NO2− were significantly higher among MCAO+PBS females (n = 7) compared to MCAO+PBS males (n = 10). LIF significantly decreased NO2− in the spleens of female rats (n = 8) compared to the MCAO+PBS female rats (n = 7; ∗p < 0.05). There was no significant difference in relative NO2− levels between MCAO+LIF male rats (n = 6) and MCAO+PBS male rats. n = 5 for male sham and n = 4 for female sham groups. (c) MCAO+LIF-treated female rats (n = 5) had significantly higher levels of IL-3 in the spleen compared to MCAO+PBS females (n = 6; ∗∗p < 0.01) and MCAO+LIF males (n = 8; ∗∗∗p < 0.001). However, there were no differences between MCAO+PBS males (n = 7) and MCAO+LIF males. n = 2 for male sham group and n = 5 for female sham group.