Table 1. Enrichment analysis of the shared DEGs in the meta-analysis according to Kobas3.0.
| Pathway ID | Enriched pathway | Database | Input no. | Background no. | p -Value |
|---|---|---|---|---|---|
| R-HSA-449147 | Signaling by interleukins | Reactome | 92 | 619 | 3.51E-30 |
| R-HSA-3700989 | Transcriptional regulation by TP53 | Reactome | 71 | 359 | 4.07E-30 |
| R-HSA-109582 | Hemostasis | Reactome | 78 | 617 | 7.22E-22 |
| R-HSA-1257604 | PIP3 activates AKT signaling | Reactome | 48 | 247 | 1.55E-20 |
| R-HSA-5633007 | Regulation of TP53 activity | Reactome | 37 | 159 | 2.29E-18 |
| R-HSA-913531 | Interferon signaling | Reactome | 39 | 194 | 2.15E-17 |
| R-HSA-449836 | Other interleukin signaling | Reactome | 43 | 275 | 1.57E-15 |
| R-HSA-446652 | Interleukin-1 family signaling | Reactome | 29 | 138 | 9.83E-14 |
| R-HSA-877300 | Interferon gamma signaling | Reactome | 23 | 90 | 1.10E-12 |
| R-HSA-9020702 | Interleukin-1 signaling | Reactome | 23 | 101 | 8.36E-12 |
| R-HSA-76002 | Platelet activation, signaling and aggregation | Reactome | 34 | 260 | 1.08E-10 |
| R-HSA-1169091 | Activation of NF-κβ in B cells | Reactome | 18 | 66 | 1.25E-10 |
| P00031 | Inflammation mediated by chemokine and cytokine signaling | PANTHER | 29 | 201 | 3.24E-10 |
| R-HSA-1234174 | Cellular response to hypoxia | Reactome | 18 | 74 | 6.08E-10 |
| P00036 | Interleukin signaling | PANTHER | 18 | 80 | 1.78E-09 |
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha | Reactome | 16 | 65 | 4.67E-09 |
| hsa04621 | NOD-like receptor signaling | KEGG | 25 | 178 | 8.51E-09 |
| hsa04657 | Interleukin -17 signaling | KEGG | 18 | 93 | 1.39E-08 |
| R-HSA-9020591 | Interleukin-12 signaling | Reactome | 13 | 47 | 4.02E-08 |
| R-HSA-447115 | Interleukin-12 family signaling | Reactome | 14 | 57 | 4.36E-08 |
| P00047 | PDGF signaling | PANTHER | 19 | 124 | 1.51E-07 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | Reactome | 17 | 108 | 4.80E-07 |
| R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after interleukin-12 stimulation | Reactome | 10 | 38 | 2.17E-06 |
| R-HSA-448424 | Interleukin-17 signaling | Reactome | 11 | 72 | 6.26E-05 |
| R-HSA-6783783 | Interleukin-10 signaling | Reactome | 8 | 47 | 0.000324 |
| hsa04610 | Complement and coagulation cascades | KEGG | 10 | 79 | 0.000523 |
| R-HSA-1059683 | Interleukin-6 signaling | Reactome | 4 | 11 | 0.001037 |
| R-HSA-9008059 | Interleukin-37 signaling | Reactome | 5 | 21 | 0.0012 |
| R-HSA-8984722 | Interleukin-35 signaling | Reactome | 4 | 12 | 0.001348 |
| R-HSA-6783589 | Interleukin-6 family signaling | Reactome | 5 | 24 | 0.002002 |
| R-HSA-5660668 | CLEC7A/inflammasome | Reactome | 3 | 6 | 0.002313 |
| R-HSA-8854691 | Interleukin-20 family signaling | Reactome | 5 | 25 | 0.002341 |
| P00011 | Blood coagulation | PANTHER | 6 | 38 | 0.00253 |
| R-HSA-2162123 | Synthesis of prostaglandins (PG) and thromboxanes (TX) | Reactome | 4 | 15 | 0.002662 |
| P00030 | Hypoxia response via HIF activation | PANTHER | 5 | 26 | 0.002719 |
| R-HSA-448706 | Interleukin-1 processing | Reactome | 3 | 8 | 0.004333 |
| R-HSA-451927 | Interleukin-2 family signaling | Reactome | 6 | 44 | 0.004852 |
| R-HSA-9020933 | Interleukin-23 signaling | Reactome | 3 | 9 | 0.005641 |
| R-HSA-512988 | Interleukin-3, interleukin-5 and GM-CSF signaling | Reactome | 6 | 47 | 0.006471 |
| R-HSA-9020956 | Interleukin-27 signaling | Reactome | 3 | 11 | 0.008903 |
| R-HSA-1234158 | Regulation of gene expression by hypoxia-inducible factor | Reactome | 3 | 11 | 0.008903 |
| R-HSA-912526 | Interleukin receptor SHC signaling | Reactome | 4 | 26 | 0.014291 |
| R-HSA-2022377 | Metabolism of angiotensinogen to angiotensins | Reactome | 3 | 18 | 0.027605 |
| R-HSA-1266695 | Interleukin-7 signaling | Reactome | 4 | 36 | 0.037224 |
| hsa04614 | Renin-angiotensin system | KEGG | 3 | 23 | 0.048055 |
Abbreviations: AKT, α serine/threonine-protein kinase; DEG, differentially expressed genes; GM-CSF, gross motor-cerebrospinal fluid; HIF, hypoxia-inducible factor; KEGG, Kyoto encyclopedia of genes and genomes; NF, nuclear factor; NOD, nucleotide-binding, oligomerization domain; PDGF, platelet-derived growth factor; JAK-STAT, janus kinase-signal transducer and activator of transcription; CLEC7A, C-type lectin domain containing 7A; SHC, Src homology 2 domain; PIP3, phosphatidylinositol (3,4,5)-trisphosphate.
Note: Input number signifies the number of hits from the meta-analysis whereas background number is from each curated gene set library. Pathways in the table were ranked based on the adjusted p-value.