Table 2. Top twenty hub genes prioritized based on the topological parameters, that is, degree using Cytoscape.
| Entrez ID | Symbol | Degree | Betweenness centrality | Closeness centrality | Combined ES | p -Value |
|---|---|---|---|---|---|---|
| 7157 | TP53 | 60 | 0.294336 | 0.369736 | −1.6588 | 0 |
| 7314 | UBB | 39 | 0.202782 | 0.349528 | 0.4802 | 0.02506 |
| 3320 | HSP90AA1 | 31 | 0.193582 | 0.352381 | 0.7022 | 0.00034 |
| 207 | AKT1 | 30 | 0.133454 | 0.342366 | −1.847 | 0.000224 |
| 983 | CD1 | 27 | 0.052607 | 0.318769 | 0.65994 | 0.000892 |
| 8850 | KAT2B | 24 | 0.0692 | 0.32134 | 0.6207 | 0.001954 |
| 10594 | PRPF8 | 23 | 0.033761 | 0.255172 | −1.5438 | 0 |
| 4088 | SMAD3 | 22 | 0.075699 | 0.31318 | −1.3522 | 5.34E-12 |
| 998 | CDC42 | 20 | 0.0827 | 0.289547 | 0.73897 | 0.005455 |
| 3184 | HNRNPD | 20 | 0.035921 | 0.27364 | −0.82441 | 0.000317 |
| 1457 | CSNK2A1 | 19 | 0.11239 | 0.315661 | −0.51181 | 0.015109 |
| 1660 | DHX9 | 18 | 0.087967 | 0.290685 | −0.43831 | 0.047395 |
| 5970 | RELA | 18 | 0.080218 | 0.323144 | −1.4588 | 2.12E-13 |
| 9978 | RBX1 | 17 | 0.019157 | 0.272202 | 1.5674 | 0 |
| 5710 | PSMD4 | 16 | 0.002551 | 0.266324 | 0.80414 | 3.19E-05 |
| 5706 | PSMC6 | 16 | 9.23E-04 | 0.267286 | 0.44812 | 0.041198 |
| 5690 | PSMB2 | 16 | 0.00169 | 0.267286 | −0.48723 | 0.022315 |
| 220988 | HNRNPA3 | 16 | 0.001619 | 0.239482 | −0.5779 | 0.004609 |
| 6429 | SRSF4 | 16 | 0.005126 | 0.239593 | −0.82971 | 1.67E-05 |
| 5591 | PRKDC | 16 | 0.055064 | 0.324765 | −1.1922 | 6.3E-10 |
Abbreviations: AKT1, α serine/threonine-protein kinase 1; CD1, cyclin-dependent 1; DHX9, DExH-box helicase 9; ES, effect size; HSP90AA1, heat shock protein 90 alpha family class-A member 1; KAT2B, lysine acetyltransferase 2B; PSMB2, proteasome 20S subunit beta; PSMD4, proteasome 26S subunit, non-ATPase 4; RBX1, RING-box protein 1; RELA, REL-associated protein; TP53, total protein 53; UBB, ubiquitin B; PRPF8, pre-mRNA-processing-splicing factor 8; CDC42, cell division control protein 42 homolog; HNRNPD, heterogeneous nuclear ribonucleoprotein D; CSNK2A1, casein kinase II subunit alpha; PSMC6, proteasome 26S subunit, ATPase 6; HNRNPA3, heterogeneous nuclear ribonucleoprotein A3; SRSF4, serine and arginine rich splicing factor 4; PRKDC, protein kinase, DNA-activated, catalytic subunit.
Note: Expression level (combined ES) and p-value was added from the meta-analysis in the table. The highlighted ones are the genes known to participate in host-viral interactions.