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. 2020 Dec 4;14:597428. doi: 10.3389/fnbeh.2020.597428

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Copyright © 2020 Sato and Yamamoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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7,11-HD plays a key role for male mate choice in the D. melanogaster species subgroup. (A) 7,11-HD is a D. melanogaster female-specific pheromone synthesized in oenocytes as mediated by enzymes including DesatF and EloF. (B) DesatF expression is female-specific in D. melanogaster and D. sechellia, whereas it is transcriptionally inactivated in D. simulans and D. mauritiana. (C) Pathways for pheromone synthesis in D. melanogaster and D. simulans. 7-T is a monoene with a double bond at the 7th carbon whereas 7,11-HD is a diene with two double bonds each at the 7th and 11th carbon as the numbers in the compound names indicate.