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. 2020 Dec 4;14:597428. doi: 10.3389/fnbeh.2020.597428

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Copyright © 2020 Sato and Yamamoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination of several GRs expressed in a single neuron determines the response spectrum of the cell. Upper left-side panel: Spatial localization of bitter-responsive I-a (blue) and I-b (red) sensilla on the labellum. Right-side panels: The bitter-responsive neuron (labeled as “B”) of each sensillum expresses a different combination of Gustatory receptors (Grs), five of which are referred to as “Commonly Expressed Receptors” (CERs; in dotted rectangles) and are expressed in every bitter-responsive neuron on the labellum. Expression of Gr32a, Gr33a, and Gr39a.a together confers a berberine sensitivity on the I-a sensillum, whereas expression of Gr33a, Gr39a.a, Gr66a, and Gr93a together confers a caffeine sensitivity on the I-b sensillum. However, the latter four Grs are unable to confer a caffeine sensitivity on the I-a sensillum, because Gr32a, Gr59b, and Gr89a are coexpressed in this sensillum.