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. Author manuscript; available in PMC: 2021 Dec 16.
Published in final edited form as: Cell Syst. 2020 Oct 7;11(6):573–588.e9. doi: 10.1016/j.cels.2020.09.005

Figure 1. Antigens presenting distinct hemagglutinin (HA) geometries.

Figure 1

(A) A/New Caledonia/20/1999 (NC99) H1N1 influenza virus with hemagglutinin (blue) and neuraminidase (red) (i). Ferritin nanoparticles presenting either full length HA (ii) or stem only trimer (iii), and free HA trimer (iv) (all are derived from NC99). (B) The 2009 H1N1 pandemic Influenza virus A/California/09/2009 (CA09). (C) The hemagglutinin ectodomain is composed of two domains: a globular head and narrowing stalk or stem region. The HA stalk-bnAb epitope (referred throughout as the “Group 1 bnAb epitope”) is depicted in yellow. HAΔstem contains the I45R, T49R substitutions that sterically present access to this site.