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. Author manuscript; available in PMC: 2021 Dec 16.
Published in final edited form as: Cell Syst. 2020 Oct 7;11(6):573–588.e9. doi: 10.1016/j.cels.2020.09.005

Figure 5. The Group 1 bnAb B cell frequency in the human antibody repertoire predicts bnAb elicitation by SS-np.

Figure 5

(A) The on-to-off stem-specific ratio of mature B cells (a proxy for Ab titers). The stem-specific on/off ratio was 1.2 (blue hexagram), similar to the stem-specific on/off ratio measured in humans, which is 1.15 (see text “Results - Part C. Validation in vivo”), or 0.2 (yellow triangle). The germline relative affinity was 1. (B) Immunogenicity heatmaps developed in silico. (i) The stem-specific on/off ratio was 1.2. fi is the fraction of memory B cells targeting an epitope of all stem specific memory B cells. To increase the visibility of residue targeted by a small fraction of B cells, the color bar shows fi1/2. (ii) The stem-specific on/off ratio was 0.2. The Group 1 bnAb epitope is marked in yellow.