. Author manuscript; available in PMC: 2021 Dec 16.

Published in final edited form as: Cell Syst. 2020 Oct 20;11(6):608–624.e9. doi: 10.1016/j.cels.2020.09.008

Table 1:

Parameters for the energies of different conformations of monomer and longitudinal and lateral interfaces. E_forbid is an arbitrary large number so that transition from any state to a state with energy of E_forbid has vanishing rate. Since there are no experimental measurements on these properties, they are assumed with two considerations: 1) they need to be in physically reasonable range for the relevant process, 2) they satisfy a list of constraints based on physical principles and relevant experimental observations detailed in the STAR Methods. Within these constraints, they are adjusted to reproduce experimentally measured kinetic data of dynamic instability in Fig. 4.

Monomer or Interface State	Energy of Monomer or Interface State (kcal/mol)	Monomer or Interface State	Energy of Monomer or Interface State (kcal/mol)
B	−10.7	ScS^D	−6.8
S	−4.6	ScC^T, S^T-c-C, ScC^D, S^D-c-C	−6.1
C	−6.4	C^D-c-S, CcS^D	−4.9
SsS^T, S^T−s−S, SsS^D	−7.4	CcC^T, C^T-c-C, C^D-c-C, CcC^D	−8.6
S^D−s−S	−5.1	BtB	−2.9
SsB^T, S^T-s-B, S^D-s-B	−1.4	StB	−2.7
SsC^T, S^T-s-C, SsC^D	−7.1	StS	−3.2
S^D-s-C	−4.7	BeB	−1.7
SbS^T, S^T-b-S	−5.7	SeB	−1.0
SbB^T, S^T-b-B, S^D-b-B	−1.2	SeS	−2.2
BbS^T, B^T-b-S	−0.74	CeB, CeS, CtB, CtS	0.36
BbB^T, B^T-b-B	−2.0	(All other states)	E_forbid
ScS^T, S^T-c-S, S^D-c-S	−5.0