Figure 4. Chimerism patterns after haplo-dCBT in patients with a transient myeloid bridge (Group 2, n = 20).
Whole blood chimerism analysis (Figure 4A) revealed short-lived haplo-identical donor engraftment (median day 14 haplo-identical donor chimerism 82%, range 0–100%) followed by sustained CB-derived hematopoiesis. Both myeloid (Figure 4B) and T-cell (Figure 4C) lineages were primarily derived from the dominant CB unit as early as day 28.
*Footnote: Red: Haplo-identical donor; Blue: Dominant (engrafting) CB unit; Green: Non-dominant (non-engrafting) unit