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. Author manuscript; available in PMC: 2021 Mar 14.
Published in final edited form as: Nature. 2020 Sep 14;588(7838):509–514. doi: 10.1038/s41586-020-2760-4

Figure 1. The trametinib binding pocket in MEK extends to the KSR interaction interface.

Figure 1.

A. Trametinib bound to KSR1:MEK1:AMP-PNP. See Extended Data Figure 1 for trametinib bound to KSR2:MEK1:AMP-PNP.

B. Trametinib contacts include A825 in the pre-helix αG loop of KSR1. Direct contacts of trametinib with MEK1 also highlighted.

C. 2D schematic of the trametinib binding pocket.