Table 3.

14 SNP associated with IVIG unresponsive in KD.

CHR	Position	SNP	Nearby Gene(s)	Region	Ref/Alt	Freq	OR	P-value	Adjusted by gender	Adjusted by age	P-value adjusted by age and gender
1	40,229,368	rs2463260	PPIE	Exonic	A/G	0.06	3.35	4.2 × 10−4	4.6 × 10–4	1.6 × 10−2	1.5 × 10−2
1	167,408,670	rs840016	CD247	Intronic	C/T	0.02	3.77	5.4 × 10−4	5.4 × 10−3	1.0 × 10−1	1.33 × 10−1
3	38,534,142	rs77317995	ACVR2B	UTR3	T/A	0.36	0.46	4.4 × 10−4	4.2 × 10−4	1.3 × 10−2	1.2 × 10−2
5	180,053,090	rs56401579	FLT4	Intronic	G/A	0.04	3.33	3.6 × 10−4	5.4 × 10−4	3.2 × 10−3	4 × 10−3
5	180,053,097	rs56193546	FLT4	Intronic	C/T	0.04	3.33	3.6 × 10−4	5.4 × 10−4	3.2 × 10−3	4 × 10−3
7	148,480,990	rs10271133	CUL1	Intronic	C/T	0.05	3.58	8 × 10−5	8.2 × 10−5	6.5 × 10−3	5 × 10−3
7	148,487,395	rs2007404	CUL1	Intronic	T/C	0.11	2.62	8.8 × 10−4	9.2 × 10−4	1.4 × 10−1	1.4 × 10−1
10	6,066,195	rs12358961	IL2RA	Intronic	T/A	0.07	2.94	4.7 × 10−4	5.5 × 10−4	1.2 × 10−1	1.4 × 10−1
15	66,727,597	rs16949924	MAP2K1	Intronic	G/C	0.05	2.97	8.8 × 10−4	9.7 × 10−4	2.2 × 10−1	2.21 × 10−1
20	36,989,335	rs2232595	LBP	Intronic	C/T	0.02	3.74	9.6 × 10−4	6.6 × 10−4	2.1 × 10−3	2 × 10−3
22	50,705,059	rs742185	MAPK11	Intronic	A/G	0.09	2.87	5.1 × 10−4	5.1 × 10−4	3.0 × 10−1	3.02 × 10−1
Y	21,153,275	rs6530599	CD24	ncRNA_intronic	A/G	0.57	0.55	7 × 10−4	8.4 × 10−4	3.6 × 10−1	3.66 × 10−1
Y	21,153,459	rs6530600	CD24	ncRNA_intronic	A/G	0.57	0.55	7 × 10−4	8.4 × 10−4	3.6 × 10−1	3.66 × 10−1
Y	21,153,474	rs1136210	CD24	ncRNA_intronic	A/G	0.57	0.55	7 × 10−4	8.4 × 10−4	3.6 × 10−1	3.66 × 10−1

Ref/Alt, reference allele and alternative allele; OR, indicates odds ratio; and UTR, untranslated region.