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. 2020 Dec 4;11:605688. doi: 10.3389/fimmu.2020.605688

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Copyright © 2020 Littera, Campagna, Deidda, Angioni, Cipri, Melis, Firinu, Santus, Lai, Porcella, Lai, Rassu, Scioscia, Meloni, Schirru, Cordeddu, Kowalik, Serra, Ragatzu, Carta, Del Giacco, Restivo, Deidda, Orrù, Palimodde, Perra, Orrù, Conti, Balestrieri, Serra, Onali, Marongiu, Perra and Chessa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The HLA alleles and haplotypes which confer susceptibility to or protection against SARS-CoV-2 infection. The figure shows the odds ratios (OR) for the significantly different frequencies observed for HLA alleles and haplotypes (HLA-B*40:02; HLA-C*04:01; HLA-A*30:02, -B*14:02; HLA-A*02:05, -B*58:01; HLA-A*30:02, -C*08:02; HLA-A*02:05, -C*07:01; HLA-A*02:05, -B*58:01, -C*07:01; HLA-A*30:02, -B*14:02, -C*08:02; HLA-A*02:05, -B*58:01, -DRB1*03:01; HLA-A*02:05, -B*18:01, -DRB1*16:01; HLA-A*02:05, -B*58:01, -C*07:01, -DRB1*03:01 and HLA-A*02:05, -B*58:01, -C*07:01, DRB1*16:01) in the two groups of COVID-19 patients and controls. The error bars, computed according to the two-tailed Fisher’s exact test, represent the 95% confidence intervals of the OR. The red line represents the threshold OR = 1 at which the HLA allele and haplotype frequencies in the two groups of patients and controls are equal.