Table 4.
Comparison of HLA allele and haplotype frequencies between patients with pauci-symptomatic/mild (Group A) and moderate/severe disease (Group S).
| Alleles/haplotypes | Healthy controls (1238 alleles) | Group A (286 alleles) | Group S (78 alleles) | |||||
|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | P | OR (95% CI) | Pc | |||
| HLA-A | ||||||||
| A*23:01 | 20 (1.6) | 0 | 4 (5.1) | 0.002 | > 2.5 | 0.034 | ||
| A*69:01 | 0 | 2 (2.6) | 0.045 | > 0.7 | 0.765 | |||
| HLA-B | ||||||||
| B*07:02 or B*07:05 | 37 (3.0) | 6 (2.1) | 6 (7.7) | 0.025 | 3.9 (1.0–14.9) | 0.950 | ||
| B*40:02 | 11 (0.9) | 6 (2.1) | 6 (7.7) | 0.029 | 3.9 (1.2–12.4) | 0.950 | ||
| HLA-C | ||||||||
| C*12:02, 12:03 | 77 (6.2) | 34 (11.9) | 2 (2.6) | 0.010 | 0.2 (0.0–0.8) | 0.120 | ||
| HLA-DRB1 | ||||||||
| DRB1*08:01 | 23 (1.9) | 0 | 4 (5.1) | 0.002 | > 2.5 | 0.024 | ||
| DRB1*11:01, 11:02, 11:03, 11:04 | 195 (15.8) | 42 (14.7) | 4 (5.1) | 0.022 | 0.3 (0.1–0.9) | 0.252 | ||
| DRB1*04:03 or DRB1*04:05 | 164 (13.2) | 32 (11.2) | 16 (20.5) | 0.038 | 2.0 (1.0–4.1) | 0.456 | ||
| Haplotypes | ||||||||
| HLA-A*02:05, B*58:01, C*07:01 | 107 (8.6) | 12 (4.2) | 0 | 0.077 | 0 (0–1.3) | 1 | ||
| HLA-A*30:02, B*14:02, C*08:02 | 13 (1.1) | 4 (1.4) | 10 (12.8) | 5.9 · 10-5 | 10.3 (2.9–46.3) | 0.022 | ||
Pc was obtained by multiplying the uncorrected P value by the number of alleles observed.
Results displaying a P or a Pc < 0.05 are in bold.