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. 2020 Dec 17;10:22265. doi: 10.1038/s41598-020-79400-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gigantol significantly inhibited the 12-LOX pathway. (a) The relative mRNA expression of Alox5, Alox12, Alox15 and COX2 in the mouse livers from the vehicle, CCl₄ and (CCl₄+ gigantol) groups. (b) The protein expression of platelet-, and leukocyte-type 12-LOX in the mouse livers at 16 h post CCl₄ injection. The representative western blot bands are shown, n = 3 western blot experiments. The quantitative results are represented as the mean ± SD, n = 6 mice in each group. ^##P < 0.01, ^#P < 0.05 versus the vehicle group; **P < 0.01, *P < 0.05 versus the CCl₄ group. Full-length blots are presented in Supplementary Figure S6.