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. 2020 Dec 17;10:22265. doi: 10.1038/s41598-020-79400-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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12-LOX inhibitors ameliorates CCl₄-induced liver injury to the same extent as gigantol. (a) Serum ALT and (b) AST levels in mice with or without gigantol (40 mg kg⁻¹ d⁻¹, po, for 7 days), baicalein (40 mg kg⁻¹ d⁻¹, ip, for 3 days) and ML351 (40 mg kg⁻¹, ip, 3 times within 24 h) pretreatment were measured at 16 h post CCl₄ injection. (c) Representative histological sections of liver tissues were stained with H&E. Symbols: black arrow-centrilobular necrosis; rectangle-tumefaction and steatosis; solid triangle-inflammatory infiltration. CV-centrilobular veins; PV-portal veins. The results are shown as the mean ± SD, n = 6 in each group. ^###P < 0.001 versus the vehicle group; ***P < 0.001, **P < 0.01 versus the CCl₄ group; ns means non-significance.