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. 2020 Dec 17;10:22265. doi: 10.1038/s41598-020-79400-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic diagram of arachidonate metabolic cascade in liver inflammation and the intervention strategies. CCl₄ activates AA metabolism and leads to increased M1-type macrophages and neutrophils, as well as elevated cytokines, chemokines and ROS levels in the liver. Oral administration of gigantol alleviates liver inflammation partly through inhibiting the JNK/cPLA2/12-LOX pathway. The image was created by using Adobe Illustrator CC 2019 (https://www.adobe.com/products/illustrator.html).