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. 2020 Dec 17;10:22190. doi: 10.1038/s41598-020-79102-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental design. C57BL/6 mice received daily oral doses of Saccharomyces cerevisiae or selenium-enriched yeast (Selemax) for 14 days starting on EAE induction (a). Body weight and clinical score were assessed daily for 15 days. On the 15th day, which corresponded to the acute disease phase, fresh stools were collected for metagenomic sequencing and the animals were then euthanized (arrow). Samples from gut-brain axis and peripheral lymphoid organs were collected to evaluate immunological parameters (b). The mRNA expression and cytokine levels were assessed on CNS (brain plus spinal cord) whereas inflammatory infiltration and demyelination were assessed on lumbar spinal cord. Inflammatory infiltration, mRNA expression and cytokine levels were assessed on small intestine and the proportion of T cells and dendritic cells subsets were evaluated in mesenteric lymph nodes. Peripheral immunological parameters as T cell and cytokine levels were evaluated in inguinal lymph nodes and spleen, respectively. This figure was created using images from Servier Medical Art Commons Attribution 3.0 Unported License (https://smart.servier.com) and image was modified with Adobe Photoshop v.22.0.0.