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. 2020 Dec 17;10:22111. doi: 10.1038/s41598-020-79185-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of G6PD and H6PD silencing on cell redox status. Total NADPH + NADP content was similar in MCF-7 (a), MDA-MB-231 (b) and A549 (c) under control condition (CTR, green), scramble siRNA (Scr, black), siRNA G6PD (red) and siRNA H6PD (blue). By contrast, NAPDH/NADP⁺ ratio was significantly decreased by either G6PD or H6PD silencing in all three cell lines (d–f). This response was paralleled by an opposite behavior of ROS cell content that was instead significantly increased by both gene silencing (g–i). Data are expressed as mean ± SD. ***p < 0.001 vs corresponding scramble.