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. 2020 Dec 17;10:22255. doi: 10.1038/s41598-020-79268-0

Figure 1.

Figure 1

Overview of Matrix-GC procedure to detect MeCP2 binding sites in silico. The Matrix-GC procedure aims at identifying genes that are bound by MeCP2, through a combination of MeCP2 position weight matrix and DNA sequence GC%. We validate this procedure through positive and negative controls using ChIP-seq data (Maunakea et al., 2013) and evaluate its performance through Receiver Operating Characteristic curves. We apply Matrix-GC to the promoters of candidate genes across neurological and neuropsychiatric disorders to generate a list of putative genes bound by MeCP2 from each disorder.