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. 2020 Dec 17;10:22255. doi: 10.1038/s41598-020-79268-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pathway enrichment analysis of neuropsychiatric and neurological disorders using ReactomePA. Bar plot of the 5 most significant results from pathway enrichment analysis of each neuropsychiatric and neurological datasets after Matrix-GC. The following disorders are represented: attention deficit hyperactivity disorder (ADHD, Orange), bipolar disorder (BIP, Brown), Alzheimer’s disease (AD, Grey), multiple sclerosis (MS, Dark Blue), Parkinson’s disease (PD, Light Blue) Huntington’s disease (HD, Green) and amyotrophic lateral sclerosis (ALS, Purple), autism database (ASD-SFARI, Yellow). Full statistical results from ReactomePA can be found in the Supplementary Information files. Control permutation analysis was carried out on randomly generated and size-matched, from hg19 human reference genome and exome subset.