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. 2020 Dec 17;10:22255. doi: 10.1038/s41598-020-79268-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Validation of Matrix-GC selected genes in transcriptomic studies in Mecp2-null mice and RTT iPSCs. Distribution of significant genes (vertical axis, in percent) against experimental groups (horizontal): blood in Mecp2^tm1.1Bird mice (Red), cerebellum in Mecp2^tm1.1Bird mice (Yellow), iPSCs-derived neurons from RTT patient (Blue, MECP2 Del ex 3–4 mutation), iPSCs-derived Neural Progenitor Cells from RTT patient (Green, MECP2 Del ex 3–4 mutation). Monte Carlo permutation analysis yields the percentage of significant genes (p value ≤ 0.5) on 1000 randomly generated and sized-matched control gene-sets. The line within the box represents the median of the distribution. The top and bottom edges of the box represent the 3rd quartile (Q3) and 1st quartile (Q1) respectively. The upper and bottom whiskers represent Q3 + 1.5 times interquartile range, and Q1 – 1.5 times the interquartile range. Empty circles represent the outlier observations in each group, solid circles the percentage of Matrix-GC filtered genes in each group. p values are reported above groups where Matrix-GC filtered genes are significant among controls.