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. 2020 Dec 4;13:232. doi: 10.3389/fnmol.2020.603409

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Copyright © 2020 Szczygieł, Danielsen, Melin, Rosenkranz, Pankratova, Ericsson, Agerman, Kokaia and Woldbye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CG01 unilateral intrahippocampal administration did not significantly affect learning and memory function (% triads) compared to CG07-AAV control vector treatment or compared to treatment naïve control rats as revealed by testing in the Y-maze test (A; n = 11–12 rats per group). Similar result was obtained in the Morris water maze test where escape latencies during learning sessions (B) and during probe tests 1 and 2 weeks after (C) did not differ significantly between the groups (n = 11–12 rats per group). Likewise, swim speed did not differ between the groups during the learning trials (D).