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. 2020 Dec 4;10:602498. doi: 10.3389/fonc.2020.602498

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Copyright © 2020 Zhang, Wang, Peng, Xu, Wang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of a metabolism-related signature by LASSO regression model. (A) Venn diagram of DEGs among three subclasses which are prognosis-related metabolic genes. (B) Cross-validation for tuning parameter selection in the proportional hazards model. (C) Heatmap of the expression levels of signature genes. (D) Distribution of risk scores in CRC subclasses. (E, F) Survival analysis of the metabolism-related signature in CRC or CRC subclasses. (G) ROC curve analysis of age, stage and risk score. (H) Multivariate Cox regression analysis of age, stage and risk score. *P < 0.05, ***P < 0.001, ****P < 0.0001. AUC, area under the curve.