Table 3.

Clinical Characteristics of patients with distinct classification in testing set.

Clinical characteristics		Total	C1	C2	C3	Chi-square	P value
		n = 556	n = 220	n = 114	n = 222
Gender	male	306	113	62	131	2.634	0.268
	female	250	107	52	91
Age	<65	210	84	39	87	0.821	0.663
	≥65	346	136	75	135
TNM stage	1–2	295	123	50	122	4.911	0.086
	3–4	261	97	64	100
T stage	Tis–T2	57	28	1	28	13.239	0.001**
	T3–T4	479	185	106	188
	NA	20	7	7	6
N stage	N0	296	124	51	121	9.36	0.053
	N1	131	53	23	55
	NX	109	36	33	40
	NA	20	7	7	6
M stage	M0	473	194	84	195	12.298	0.002**
	M1–MX	63	19	23	21
	NA	20	7	7	6
TP53 Mutation	M	188	89	34	65	7.931	0.019*
	WT	156	51	32	73
	NA	212	80	48	84
KRAS Mutation	M	213	72	39	102	8.307	0.016*
	WT	322	136	72	114
	NA	21	12	3	6
BRAF Mutation	M	49	2	23	24	34.24	<0.0001***
	WT	453	192	85	176
	NA	54	26	6	22

*P < 0.05, **P < 0.01, ***P < 0.001. M, Mutation; WT, Wild Type.

NA, Not Available.