Table 1.
Clinical features of PIMS patients.
| Study | Godfred-clato (44) | Whittaker (14) | Toubiana (45) | Pouletty (16) | Verdoni (20) | Belhadjer (19) | Webb (46) |
|---|---|---|---|---|---|---|---|
| Number of patients | 570 | 58 | 21 | 16 | 10 | 35 | 23 |
| Age, median, (interquartile) | 8 (4-12) | 9 (5.7–14) | 7.9 (3.7–16.6) | 10 (4.7–12.5) | 7.3 (5.4–8.5) | 10 (NA) | 6.59 (4.75–8.43) |
| Male | 316 (55.4) | 25 (43) | 9 (43) | 8 (50) | 7 (70) | 18 (51) | 17 (73.9) |
| Ethnicity | |||||||
| Hispanic | 187 (40.5) | ||||||
| Black, non–hispanic | 153 (33.1) | 22 (38) | 24 (57) | 18 (73.9) | |||
| White, non–hispanic | 61 (13.2) | 12 (21) | 12 (29) | 0 | |||
| Other | 30 (5.6) | 6 (10) | 2 (5) | 5 (21.7) | |||
| Multiple | 18 (3.9) | ||||||
| Asian | 13 (2.8) | 18 (31) | 4 (10) | ||||
| Unknown | 108 (—) | ||||||
| Organ involvement | |||||||
| Gastrointestinal | 518 (90.9) | 21 (100) | 13 (81) | 6 (60) | 29 (83) | ||
| Abdominal pain | 353 (61.9) | 31 (53) | 15 (65.2) | ||||
| Vomiting | 352 (61.8) | 26 (45) | |||||
| Diarrhea | 303 (53.2) | 30 (52) | 6 (60) | 13 (56.5) | |||
| Cardiovascular | 493 (86.5) | 21 (91.3) | |||||
| Shock | 202 (35.4) | 29 (50) | 11 (69) | 5 (50) | 28 (80) | ||
| Elevated troponin | 176 (30.9) | 17 (81) | 35 (100) | ||||
| Elevated BNPa or proBNP | 246 (43.2) | 29/29 | 14/18 | 10 (100) | 28/28 | ||
| Congestive heart failure | 40 (7.0) | 35 (100) | 8 (34.8) | ||||
| Cardiac dysfunction | 207 (40.6) | 1 (3) | |||||
| Myocarditis | 130 (22.8) | 16 (76) | 7 (44) | ||||
| Coronary artery dilatation or aneurysm | 95 (18.6) | 8 (14) | 5 (24) | 3 (19) | 2 (20) | 6 (17%) | 1 (4.3) |
| Hypotension | 282 (49.5) | 13 (56.5) | |||||
| Pericardial effusion | 122 (23.9) | 10 (48) | 4 (25) | 4 (40) | 7 (30.4) | ||
| Mitral regurgitation | 130 (25.5) | 4 (40) | 7 (30.4) | ||||
| Dermatologic and mucocutaneous | 404 (70.9) | ||||||
| Rash | 315 (55.3) | 30 (52) | 16 (76) | 13 (81) | 6 (60) | 20 (57) | 20 (87.0) |
| Mucocutaneous lesions | 201 (35.3) | 17 (29) | 16 (76) | 14 (87) | |||
| Conjunctival injection | 276 (48.4) | 26 (45) | 17 (81) | 15 (94) | 7 (70) | 15 (65.2) | |
| Swollen hands and feet | 9 (16) | 11 (68) | 5 (50) | ||||
| Respiratory | 359 (63.0) | 12 (21) | 2 (12) | 23 (65) | 10 (43.5) | ||
| Cough | 163 (28.6) | ||||||
| Shortness of breath | 149 (26.1) | ||||||
| Chest pain or tightness | 66 (11.6) | 6 (17) | |||||
| Pneumonia | 110 (19.3) | ||||||
| ARDSb | 34 (6.0) | ||||||
| Pleural effusion | 86 (15.8) | ||||||
| Neurologic | 218 (38.2) | 6 (29) | 9 (56) | 11 (31) | 5 (22.7) | ||
| Headache | 186 (32.6) | 15 (26) | 5 (22.7) | ||||
| Confusion | 5 (9) | ||||||
| Meningism | 11 (31) | ||||||
| Renal | 105 (18.4) | 10 (43.5) | |||||
| Acute kidney injury | 105 (18.4) | 13 (22) | 11 (52) | ||||
| Other | |||||||
| Periorbital oedema | 27 (4.7) | ||||||
| Lymphadenopathy | 76 (13.3) | 9 (16) | 12 (57) | 21 (60) | |||
| Sore throat | 6 (10) | ||||||
| Anosmia | 1 (6) | ||||||
| Arthritis | 1 (6) | 8 (34.8) | |||||
| Rhinorrhoea | 15 (43) |
Review of 7 studies with at least 10 patients reported. Total of patients: 733.
a
B-type Natriuretic Peptide.
b
Acute Respiratory Distress Syndrome. Gray cells are data for which the study does not give information. Every cell is displayed with the number of patients and (percentage). Cells with no percentages are when not all the patients of the study had reported data. Organ involvement are not detailed due to differences of definition by each study, it was included when organ affection was described. Gray cells are for when data were not available. Blue and orange cells are for presentation.